Hi ThenRich and welcome to our forum!
You don't want to use Full Trust. It's just a bad idea because it complicates deployment (you have to install certificates). Where are you publishing to when you get the error message? Try publishing to a website using Domain Trust and then opening from that website (double click on XSN) or click Fill Out a Form for SharePoint.
Patrick Halstead [InfoPath MVP]
InfoPathDev
Patrick Halstead
Project Manager at Qdabra