Hello,
Can you check once the below code first before setting the value to that node,
//Check your node XPath should be correct
Dim mONNAIENode = MainDataSource.CreateNavigator().SelectSingleNode("/my:mesChamps/my:NOM_MONNAIE", Me.NamespaceManager)
If ‘mONNAIENode' node is not null then you can try to set the value,
mONNAIENode.text = sLibelle