Actually, qRules won't work in Office 365 any longer - Sandbox has been deprecated there and we can't admin deploy forms in O365. See the announcement toward the top of the page here for more info on that. We have not tested all commands in SharePoint 2016, which is why we don't state SP 2016 compatibility. However, I do know we have some users that are using their qRules forms on SharePoint 2016 sites, so to the best of my knowledge, there is nothing special to be done - qRules is just code, so as long as you can publish a form with code, you should be fine.
Hilary Stoupa
