This is what I already did about a dozen times. I tried changing single words, saving, then reopening (all in design mode). I tried changing a whole layout table, even selecting all as you suggested, and still got the same results. It acted exactly as if I hadn't saved, but trust me, I did.
It almost seems like Infopath doesn't terribly agree with changing the formatting of two differently-formatted sections at the same time. So, if I have a some 10-font Verdana and 12-font Times, highlight them both, then try to change them to 10-font Times, it doesn't save correctly. Sounds crazy, but that's almost what seems to be happening. I have since then been chaning just one line or one cell at a time and it seems to be working. Let's face it, Infopath's formatting abilities just kind of suck.
Thanks for your advice.